Table 2.
Biodistribution of 111In-labeled anti-CD73 antibody 063-213 in healthy rats.
| 6 h | 24 h | 48 h | 96 h | |
|---|---|---|---|---|
| Blood | 11.9 ± 1.7 | 7.6 ± 1.7 | 5.9 ± 0.6 | 4.2 ± 0.6 |
| Thymus | 1.0 ± 0.2 | 1.0 ± 0.1 | 0. 8 ± 0.1 | 0.7 ± 0.1 |
| Lung | 4.2 ± 0.5 | 3.0 ± 0.5 | 2.5 ± 0.2 | 1.9 ± 0.1 |
| Liver | 3.7 ± 0.5 | 2.6 ± 0.5 | 1.9 ± 0.3 | 1.6 ± 0.1 |
| Spleen | 2.6 ± 0.2 | 2.4 ± 0.2 | 2.0 ± 0.3 | 1.5 ± 0.2 |
| Pancreas | 1.1 ± 0.1 | 1.2 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.05 |
| Stomach | 1.1 ± 0.1 | 0.9 ± 0.1 | 0.7 ± 0.1 | 0.6 ± 0.03 |
| Intestine | 2.0 ± 0.2 | 1.4 ± 0.2 | 1.2 ± 0.1 | 0.9 ± 0.04 |
| Kidney | 3.8 ± 0.4 | 3.0 ± 0.4 | 2.6 ± 0.3 | 2.6 ± 0.2 |
| Muscle | 0.6 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.6 ± 0.04 |
| Bone | 1.8 ± 0.3 | 1.4 ± 0.3 | 1.1 ± 0.1 | 1.0 ± 0.1 |
Data are represented as the mean of %ID/g ± standard deviation (n = 4).