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. 2020 Apr 1;21(7):2454. doi: 10.3390/ijms21072454

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Persistent and resurgent currents. (A) A raw current trace from a human embryonic kidney (HEK) cell expressing hNav1.2 cDNA. Peak resurgent current (blue box) was measured as the peak current occurring during the repolarization pulse in the resurgent current voltage protocol (single step from the protocol shown above the trace). (B) A raw current trace from an HEK cell expressing hNav1.2 cDNA. Peak persistent current (blue box) was measured as the average current over the last 5 ms of a 50 ms depolarization pulse (shown above the trace). Inset shows persistent current, amplified 5×.