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. 2020 Apr 5;21(7):2519. doi: 10.3390/ijms21072519

Figure 2.

Figure 2

Effect of recombinant human soluble thrombomodulin (rTM) on the survival and blood urea nitrogen (BUN) level in the development of acute kidney injury after lipopolysaccharide (LPS) injection. (A) Survival of control and rTM-treated mice subjected to sepsis by LPS-injection. Mice were evaluated until 48 h after LPS-injection (control, n = 20; rTM, n = 20; ** p < 0.01). (B) Renal function of control and rTM-treated mice at 0 (control, n = 5; rTM, n = 5), 24 (control, n = 18; rTM, n = 16), and 48 h (control, n = 8; rTM, n = 12; ** p < 0.01) before and after LPS-injection, assessed by BUN levels. The data are the mean values ± standard error of the mean (* p < 0.05, control versus rTM-treated mice). Dotted lines represent mean values from saline-treated mice without LPS.