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. 2020 Apr 5;21(7):2519. doi: 10.3390/ijms21072519

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of recombinant human soluble thrombomodulin (rTM) on the production of inflammatory cytokines after lipopolysaccharide (LPS) injection. Serum tumor necrosis factor (TNF), interferon (IFN)-γ, interleukin (IL)-10, and IL-18 production was measured as a biomarker of AKI at 0 (control and rTM, n = 3), 4 (n = 7 and 6), 24 (n = 4 and 5), and 48 h (n = 5 and 6) before and after LPS-injection. The data are the mean values ±standard error of the mean (* p < 0.05, control versus rTM-treated mice).