a-EJ	Alternative end joining
ALS	Amyotrophic lateral sclerosis
ALT	Alternative lengthening of telomeres
APB	ALT-associated promyelocytic leukemia body
ATM	Ataxia telangiectasia mutated
ATR	Ataxia telangiectasia and Rad3-related
cGAS	Cyclic GMP-AMP synthase
cfDNA	Cell-free DNA
CNS	Central nervous system
CNV	Copy number variant
CSR	Class switch recombination
CtIP	Carboxy-terminal binding protein (CtBP) interacting protein
DDR	DNA-damage response
DSB	Double-strand break
ecc/ecDNA	Extrachromosomal circular DNA
ECTR	Extrachromosomal telomere repeat
EGFR	Epidermal growth factor receptor
ERC	Extrachromosomal rDNA circle
FA	Friedreich’s ataxia
GC	Guanine-cytosine
HD	Huntington’s disease
hESC	Human embryonic stem cells
hiPSC	Human induced pluripotent stem cells
hMOG	Human myelin oligodendrocyte glycoprotein
HR	Homologous recombination
hSOD1	Human superoxide dismutase 1
hTERT	Human telomerase reverse transcriptase
hTR	Human telomerase RNA
LINE	Long interspersed nuclear element
LTR	Long terminal repeat
LCR	Low copy repeat
LRP4	Low-density lipoprotein-related receptor protein 4
MAM	Methylazoxymethanol
MG	Myasthenia gravis
MM-EJ	Microhomology-mediated end joining
MMR	Mismatch repair
MRN	MRE11-RAD50-NBS1 complex
MSH3	MutS homolog 3
NAHR	Non-allelic homologous recombination
NBS1	Nijmegen breakage syndrome 1
NHEJ	Non-homologous end joining
NPC	Nuclear pore complex
Nup	Nucleoporin
RLS	Replicative lifespan
POT1	Protection of telomere 1
rDNA	DNA encoding for ribosomal RNA
ROS	Reactive oxygen species
SAGA	Spt-Ada-Gcn5 acetyltransferase
SAM	Senescence associated mice
SASP	Senescence associated secretory phenotype
SD	Segmental duplication
SEP	Senescence entry point
SINE	Short interspersed nuclear element
siRNA	Small interfering RNA
SpcDNA	Small polydisperse circular DNA
SSA	Single-strand annealing
SSB	Single-strand break
STING	Stimulator of interferon genes
SV	Structural variant
TE	Transposable element
TERRA	Telomeric repeat-containing RNA
Tpr	Translocation promoter region
TRD	Telomere rapid deletion
TREX-2	Transcription and export complex-2
TRF2	Telomeric repeat binding factor 2
T-SCE	Telomeric sister chromatid exchange
5′-UTR	5′-untranslated region
WGS	Whole-genome sequencing
XRCC3	X-ray repair cross-complementing 3