Table 1.
Different IS and polarized secretory traffic in T lymphocyte IS and B lymphocyte IS.
| CTL/APC | Th/APC | B/APC | B/Th | |
|---|---|---|---|---|
| Exosome secretion | + [17] | + [15] | Unknown 1 | + [16] |
| MTOC polarization | + [45] | + [95] | + [90] | + [94] |
| Secretory granules polarization | Lytic granules, MVB [29] | Lymphokine-containing granules, MVB [15,49] | SL, MHC-II+ compartment [90] | MHC-II+ compartment [94] |
| DAG/DGK-control of MTOC polarization | + [69] | + [15,69] | Unknown | Unknown |
| PKC/PKD control of secretory granules/MVB traffic | + (PKCδ, PKCθ) 2 [34,73,96] | + (PKCδ) [84] (PKD1/2) [59] | + (PKCζ) [88,90] (PKD1/3) [59] | Unknown |
| F-actin reorganization at IS | + (CDC42/WASP/ARP2/3, Formins: FMNL1, Dia1) [31] | + (CDC42/WASP/ARP2/3) (Formins: FMNL1, Dia1) [49,97] | + (CDC42/WASP/ARP2/3) Ezrin, Moesin) [32] | Unknown (TAGNL2?) [98] |
| F-actin reduction at cSMAC and MTOC polarization | + [46] | + (PKCδ dynein) [50,51,52,84] | + (dynein, proteasome) [99,100] | Unknown |
| F-actin reduction at MTOC and MTOC polarization | Unknown | Unknown | + (Proteasome) [100,101] | Unknown |
1 Formal proof has not been obtained, although indirect evidence exists. 2 Brackets indicate the molecular components involved.