Table 2.
Correlation Analysis between TDO2 Markers of Immune Cells in TIMER
| Descriptions | Gene Markers | None |
Purity Adjusted |
||
|---|---|---|---|---|---|
| Correlation | p | Correlation | p | ||
| CD8+ T cell | CD8A | 0.245174 | ∗∗∗ | 0.247093 | ∗∗∗ |
| CD8B | 0.208377 | ∗∗∗ | 0.207519 | ∗∗∗ | |
| T cell (general) | CD3D | 0.295458 | ∗∗∗ | 0.290558 | ∗∗∗ |
| CD3E | 0.284067 | ∗∗∗ | 0.278572 | ∗∗∗ | |
| CD2 | 0.334967 | ∗∗∗ | 0.331989 | ∗∗∗ | |
| B cell | CD19 | 0.231611 | ∗∗∗ | 0.223418 | ∗∗∗ |
| CD79A | 0.215303 | ∗∗∗ | 0.206306 | ∗∗∗ | |
| Monocyte | CD86 | 0.394471 | ∗∗∗ | 0.399875 | ∗∗∗ |
| CD115 (CSF1R) | 0.19243 | ∗∗∗ | 0.194018 | ∗∗∗ | |
| TAM | CCL2 | 0.377172 | ∗∗∗ | 0.376796 | ∗∗∗ |
| CD68 | 0.37994 | ∗∗∗ | 0.391855 | ∗∗∗ | |
| IL10 | 0.414858 | ∗∗∗ | 0.431181 | ∗∗∗ | |
| M1 macrophage | INOS (NOS2) | 0.075771 | ∗ | 0.081674 | ∗ |
| IRF5 | 0.253776 | ∗∗∗ | 0.255338 | ∗∗∗ | |
| COX2(PTGS2) | 0.049728 | 0.09926 | 0.047829 | 0.131641 | |
| M2 macrophage | CD163 | 0.384785 | ∗∗∗ | 0.396327 | ∗∗∗ |
| VSIG4 | 0.230386 | ∗∗∗ | 0.241997 | ∗∗∗ | |
| MS4A4A | 0.337152 | ∗∗∗ | 0.348611 | ∗∗∗ | |
| Neutrophils | CD66b (CEACAM8) | 0.037856 | 0.209634 | 0.037391 | 0.238641 |
| CD11b (ITGAM) | 0.179053 | ∗∗∗ | 0.179193 | ∗∗∗ | |
| CCR7 | 0.263431 | ∗∗∗ | 0.255275 | ∗∗∗ | |
| Natural killer cell | KIR2DL1 | 0.248415 | ∗∗∗ | 0.262995 | ∗∗∗ |
| KIR2DL3 | 0.270892 | ∗∗∗ | 0.270489 | ∗∗∗ | |
| KIR2DL4 | 0.377769 | ∗∗∗ | 0.381431 | ∗∗∗ | |
| KIR3DL1 | 0.261523 | ∗∗∗ | 0.25955 | ∗∗∗ | |
| KIR3DL2 | 0.276474 | ∗∗∗ | 0.269903 | ∗∗∗ | |
| KIR3DL3 | 0.147658 | ∗∗∗ | 0.154768 | ∗∗∗ | |
| KIR2DS4 | 0.210854 | ∗∗∗ | 0.210864 | ∗∗∗ | |
| Dendritic cell | HLA-DPB1 | 0.177509 | ∗∗∗ | 0.177217 | ∗∗∗ |
| HLA-DQB1 | 0.203416 | ∗∗∗ | 0.204322 | ∗∗∗ | |
| HLA-DRA | 0.295315 | ∗∗∗ | 0.293571 | ∗∗∗ | |
| HLA-DPA1 | 0.232387 | ∗∗∗ | 0.233481 | ∗∗∗ | |
| BDCA-1(CD1C) | 0.057982 | 0.054546 | 0.044691 | 0.158939 | |
| BDCA-4(NRP1) | 0.082773 | ∗∗ | 0.099865 | ∗∗ | |
| CD11c (ITGAX) | 0.278226 | ∗∗∗ | 0.277131 | ∗∗∗ | |
| Th1 | T-bet (TBX21) | 0.302566 | ∗∗∗ | 0.298116 | ∗∗∗ |
| STAT4 | 0.251384 | ∗∗∗ | 0.247076 | ∗∗∗ | |
| STAT1 | 0.415731 | ∗∗∗ | 0.421584 | ∗∗∗ | |
| IFN-γ (IFNG) | 0.357511 | ∗∗∗ | 0.358795 | ∗∗∗ | |
| TNF-α (TNF) | 0.217439 | ∗∗∗ | 0.208063 | ∗∗∗ | |
| Th2 | GATA3 | −0.31958 | ∗∗∗ | −0.30945 | ∗∗∗ |
| STAT6 | −0.20079 | ∗∗∗ | −0.20855 | ∗∗∗ | |
| STAT5A | −0.03753 | 0.213554 | −0.04649 | 0.142772 | |
| IL13 | 0.184803 | ∗∗∗ | 0.171661 | ∗∗∗ | |
| Tfh | BCL6 | −0.12198 | ∗∗∗ | −0.13259 | ∗∗∗ |
| IL21 | 0.286359 | ∗∗∗ | 0.291807 | ∗∗∗ | |
| Th17 | STAT3 | −0.06799 | ∗ | −0.06881 | ∗ |
| IL17A | 0.214299 | ∗∗∗ | 0.224482 | ∗∗∗ | |
| Treg | FOXP3 | 0.405434 | ∗∗∗ | 0.396407 | ∗∗∗ |
| CCR8 | 0.438307 | ∗∗∗ | 0.437575 | ∗∗∗ | |
| STAT5B | −0.1762 | ∗∗∗ | −0.17439 | ∗∗∗ | |
| TGFβ (TGFB1) | 0.031626 | 0.294651 | 0.041407 | 0.191877 | |
| T cell exhaustion | PD-1 (PDCD1) | 0.279633 | 3.29E−21 | 0.272028 | ∗∗∗ |
| CTLA4 | 0.421275 | 1.49E−48 | 0.41456 | ∗∗∗ | |
| LAG3 | 0.39448 | 2.85E−42 | 0.395075 | ∗∗∗ | |
| TIM-3 (HAVCR2) | 0.340601 | 2.79E−31 | 0.350868 | ∗∗∗ | |
| GZMB | 0.435824 | 3.28E−52 | 0.429831 | ∗∗∗ | |
TAM, tumor associated macrophage. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.