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(A) Membrane lipids and GM2AP do not affect the hydrolysis of artificial, water-soluble substrate fluorogenic 4-methylumbelliferyl-6-sulfo-2-acetamido-2-deoxy-β-d-glycopyranoside (MUGS) by Hex A but (B) they strongly affect and regulate the catabolism of liposome-bound radiolabeled native GM2, reflecting the in vivo conditions at the ILVs. This figure is modified from [6].
