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Pancreatic beta-cell development. A flow diagram depicting various lineages of stem cell differentiation toward pancreatic cell progeny. Signaling pathways, as well as markers for various cell types, are shown. i: Inhibitor; DE: Definitive endoderm; (PGT) posterior gut tube, PE: pancreatic endoderm, PPs: pancreatic progenitors; EPs: endocrine progenitor cells.
