Figure 4.

gp120 increases the release of ATP via the activation of Panx1 channels. ATP release normalized to the control (dashed line) by astrocytes stimulated for 24 h with 10 ng/mL gp120 alone or plus the following agents: 100 µM Tat-L2, 100 µM gap19, 100 µM ¹⁰panx1 and 500 µM Probenecid (Prob). * p < 0.01, gp120 vs. control; # p < 0.01, pharmacological agents vs. gp120. Data were obtained from at least three independent experiments (see scatter dot plot) with three or more repeats each one.