The carotenoid (A) and chlorophyll (B) metabolic pathway in tobacco leaves during curing. Up-regulated proteins or increased metabolites are marked with upward red arrows, while down-regulated proteins or decreased metabolites are marked with downward green arrows. The numbers represent the fold change. The left arrows or numbers represented the difference of proteins or metabolites during 0–48 h, the middle arrows or numbers indicated the difference during 0–72 h, and the right indicated the difference during 48–72 h. Gi numbers and ratios of the DEPs are shown in Supplementary Table S4. (A) GGPP, geranylgeranyl diphosphate; PSY, phytoene synthase; PDS, phytoene desaturase; ZDS, ζ-carotene desaturase; CRTISO, carotenoid isomerase; LCYB, lycopene β-cyclase; LCYE, lycopeneε-cyclase; BCH, β-carotene hydroxylase; NSY, neoxanthin synthase. (B) Chlide a/b, chlorophyllide a/b; MCS, metal-chelating substance; CAO, chlorophyllide-a oxygenase; Pheide a, pheophorbide a; Chl a/b, chlorophyll a/b; 7HChl a, 7-Hydroxy-chlorophyll a; NCCs, non-fluorescent chlorophyll catabolites.