Table 2.

Summary of selected tumor suppressor miRNAs with their functional effects in glioblastoma.

Major Tumor Suppressor miRNAs in Glioblastoma
MicroRNA	Validated Targets	Functional Effects in Glioblastoma	References
hsa-mir-34a	SIRT1, c-Met, Notch1/2, PDGFRA, Msi1	Inhibits cell proliferation, cell cycle progression, cell survival, invasion, and tumor growth in vivo	[125,126]
hsa-miR-128	WEE1, p70S6K1, Msi1, E2F3a, SUZ12, Bmi-1, EGFR, PDGFRα, ANGPTL6	Decreases radioresistance, attenuates cell proliferation, tumor growth and angiogenesis	[105,108,110,111,112,127]
hsa-miR-137	RTVP-1, COX-2, EGFR, CDK6, RTVP-1 Rac1	Inhibits proliferation and invasion and reduces stemness; increases apoptosis and promotes cell cycle arrest	[120,121,124,128]
hsa-miR-124	AURKA, SOS1	Inhibits proliferation, reduces stemness, promotes cell cycle arrest and increases chemosensitivity.	[121,129,130]
hsa-miR136	AEG-1, Bcl-2	Promotes apoptosis and increases chemosensitivity	[131,132]
hsa-miR-181b	FOS, MEK1, IGF-1R, CCL8, MDM2	Inhibits proliferation, migration, and invasion; promotes cell cycle arrest; suppresses angiogenesis and tumor growth in vivo	[114,116,117,119,133,134]
hsa-miR-195	E2F3, CCND3, Cyclin D1, Cyclin E1	Inhibits proliferation, migration, and invasion; promotes cell cycle arrest and reduces tumor growth in vivo	[135,136]
hsa-miR-139-5p	ELTD1, Notch1	Inhibits proliferation and invasion; promotes apoptosis; reduces tumor growth and prolongs survival in vivo	[103,104]