Table 4.
Summary of selected tumor suppressor lncRNAs with their potential roles in glioblastoma.
| Major Tumor Suppressor LncRNAs in Glioblastoma | ||||
|---|---|---|---|---|
| LncRNA | Target miRNA | Mechanism of Action | Functional Effects in Glioblastoma | References |
| RAMP2-AS1 | - | Interacts with DHC10/NOTCH3/HES1-signaling pathway | Reduces tumor growth | [140] |
| CASC2 | miR-21 miR-193a-5p |
Binds directly to miRNA, suppresses the Wnt/β-catenin signaling pathway and regulates mTOR expression | Inhibits autophagy and malignancy in glioblastoma cells, sensitizes GSCs to TMZ-treatment leading to ferroptosis | [200,203] |
| GAS5 | miR-222 miR-196a-5p miR-18a-5p |
Acts as a molecular sponge for miRNAs | Promotes proliferation in glioblastoma cells and GSCs; prognostic predictor of survival | [204,205,206] |