Table 2.
Activity of 1–8 and cisplatin in three-dimensional (3D) cell cultures a.
| IC50 ± SD (μM) | ||
|---|---|---|
| H157 | BxPC3 | |
| 1 | 4.7 ± 0.3 | 3.1 ± 0.5 |
| 2 | 3.3 ± 1.0 | 2.4 ± 0.2 |
| 3 | 10.9 ± 3.0 | 4.5 ± 1.3 |
| 4 | 2.7 ± 0.5 | 6.5 ± 1.1 |
| 5 | 11.9 ± 2.0 | 10.2 ± 2.3 |
| 6 | 10.0 ± 0.4 | 5.5 ± 0.9 |
| 7 | 13.0 ± 1.1 | 8.5 ± 0.9 |
| 8 | 2.9 ± 0.5 | 1.2 ± 0.2 |
| Cisplatin | 52.51 ± 1.31 | 100.5 ± 12.1 |
a Spheroids (2.5 × 103 cells/well) were treated for 72 h with increasing concentrations of tested compounds. The growth-inhibitory effect was evaluated by means of the acid phosphatase (APH) test. IC50 values were calculated from the dose–survival curves using a four-parameter logistic model (p < 0.05). SD = standard deviation.