. 2020 Apr 7;5(15):8515–8522. doi: 10.1021/acsomega.9b04038

Table 1. Optimization of the Synthesis of Compound 3a^a^,^b ^a.

entry	base	solvent	MW power (W)	irradiation time (min)	% yield 3a^c
1	Et₃N	CH₃CN	100	4	60
2	Et₃N	CH₃CN	100	6	75
3	Et₃N	CH₃CN	100	8	65
4	Et₃N	CH₃CN	200	2	60
5	Et₃N	CH₃CN	200	4	85
6	Et₃N	CH₃CN	200	6	82
7	Et₃N	CH₃CN	300	2	65
8	Et₃N	CH₃CN	300	4	80
9	K₂CO₃	CH₃CN	200	4	92^d
10	Na₂CO₃	CH₃CN	200	4	87
11	CaH₂	CH₃CN	200	4	85
12	K₂CO₃	DMF	200	4	90
13	K₂CO₃	toluene	200	4	90
14	K₂CO₃	CH₃CN			83^e

Reaction conditions: All of the reactions were carried out on a CEM Discover-300 microwave synthesizer.

Power mode, 50 psi.

Isolated yield.

Optimized condition.

Reflux for 12 h.

Table 1. Optimization of the Synthesis of Compound 3aa,ba.