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. 2020 Apr 7;5(15):8557–8563. doi: 10.1021/acsomega.9b04371

Figure 1.

Figure 1

(A) Line structures of LΔF, fMLF isoniazid, ciprofloxacin, and amphotericin B. (B) Inversion test showing self-supporting hydrogels of LΔF alone (upper) and LΔF + fMLF (1:1) (lower) and cartoons of hydrogels and the nanofibers comprising them in each case. (C) Cryo-transmission electron microscopy (cryo-TEM) analysis of LΔF (upper) and LΔF + fMLF (1:1) (lower) hydrogels. (D) Time-dependent step-strain rheological tests of LΔF and LΔF + fMLF (1:0.5) showing injectability and self-healing properties. Confocal microscopy images showing viability of (E) U937 macrophages and (F) fibroblasts in 1% w/v LΔF + fMLF (1:0.5). (G) Monocyte/macrophage migration assay with untreated cells, LΔF alone, and 1% w/v LΔF + fMLF (1:0.25). (H) Release profiles for isoniazid, ciprofloxacin, and amphotericin B from 1% w/v LΔF + fMLF (1:0.25) hydrogel over a period of 5 days. (I) Release profile for ciprofloxacin from 0.5, 1, or 2% w/v LΔF + fMLF (1:0.25) hydrogel over a period of 5 days.