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. 2020 Jan 8;36(8):2578–2580. doi: 10.1093/bioinformatics/btz963

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — The overall workflow of DeepSimulator as well as the differences between DS1.5 and DS1.0. In brief, the DeepSimulator framework contains three modules: sequence generator, signal generator and basecaller. As shown in the last two rows, DS1.5 is significantly improved from DS1.0, with a greatly enhanced sequence generator and signal simulator, multiple new components as well as numerous optimizations. More discussions about the improvement of DS1.5 over DS1.0 can be referred to Section 2, Supplementary Sections S4 and S5