T
|
set of transcripts in a gene; Ti denotes the ith transcript of the gene |
l
|
lengths of transcripts; li denotes the length of transcript Ti
|
r
|
set of reads aligned to a gene; rj is the jth read aligned to the gene |
P
|
the probability of a read generated by the transcripts in the gene, |
|
specifically, P=
|
|
the effective lengths of the transcripts, where , |
|
li and lr are the length of Ti and the length of the read respectively |
qij
|
read sampling probability, if read rj is aligned to Ti, |
|
otherwise qij = 0 |
E
|
the transcripts’ expressions in NanoString or Exon-array platform |
aij
|
a soft assignment of read rj to transcript Ti in the EM algorithm |
α
|
a scaling factor between the transcript expressions in different platforms |
λ
|
hyper-parameter |