Table 1.
Antimicrobial activity of silver(I) complexes 1–3 and the respective bpa and bpe ligands (MIC, μg/mL) in comparison to their cytotoxic effect on the normal human fibroblast cell line MRC-5 (IC50, μg/mL).
| Test organism | Compound | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | bpa | bpe | |
|
E. coli
NCTC 9001 |
12.5a | 12.5 | 12.5 | >500 | 250 |
|
P. aeruginosa
PAO1 |
50 | 200 | 25 | >500 | 500 |
|
L. monocytogenes
NCTC 11994 |
50 | 50 | 25 | >500 | 100 |
|
S. aureus
ATCC 43300 |
50 | 200 | 100 | >500 | >500 |
|
E. faecalis
ATCC 29212 |
12.5 | 25 | 25 | >500 | >500 |
|
S. enteritidis
ATCC 13075 |
50 | 50 | 200 | >500 | >500 |
|
S. pullorum
ATCC 13036 |
25 | 12.5 | 250 | >500 | >500 |
|
C. albicans
ATCC 10231 |
6.25 | 6.25 | 25 | 125 | 200 |
|
C. parapsilosis
ATCC 22019 |
3.1 | 2.5 | 3.1 | 250 | 125 |
|
C. glabrata
ATCC 2001 |
6.25 | 12.5 | 25 | >500 | 100 |
|
C. krusei
ATCC 6258 |
6.25 | 3.1 | 6.25 | 125 | 200 |
| MRC-5 cells | 40b | 30 | 40 | 300 | 220 |
aResults are given as mean of three independent measurements with a standard error being between 1% and 3%. bCalculated IC50 values correspond to the concentrations required to inhibit 50% of the cell growth.