Table 2.
The allelic and genotypic distribution among control, CIN and cervical cancer groups of SNPs in ERAP1 gene
| SNPs | Control (Freq) | CIN (Freq) | Cervical cancer (Freq) | Cervical cancer vs Control | CIN vs Control | Cervical cancer vs CIN | |||
|---|---|---|---|---|---|---|---|---|---|
| P-value | OR[95%CI] | P-value | OR[95%CI] | P-value | OR[95%CI] | ||||
| rs27037 | |||||||||
| G | 1372 (54.4%) | 592 (53.2%) | 1092 (50.9%) | 0.020 | 1.147 [1.022–1.288] | 0.532 | 1.046 [0.908–1.205] | 0.212 | 1.097 [0.949–1.268] |
| T | 1152 (45.6%) | 520 (46.8%) | 1052 (49.1%) | ||||||
| G/G | 359 (28.4%) | 161 (29.0%) | 283 (26.4%) | 0.020 | 0.323 | 0.462 | |||
| G/T | 654 (51.8%) | 270 (48.6%) | 526 (49.1%) | ||||||
| T/T | 249 (19.8%) | 125 (22.5%) | 263 (24.5%) | ||||||
| rs27044 | |||||||||
| G | 1350 (53.5%) | 611 (54.9%) | 1240 (57.8%) | 0.003 | 0.838 [0.746–0.941] | 0.416 | 0.943 [0.818–1.086] | 0.114 | 0.889 [0.768–1.029] |
| C | 1174 (46.5%) | 501 (45.1%) | 904 (42.2%) | ||||||
| G/G | 362 (28.7%) | 175 (31.5%) | 360 (33.6%) | 0.012 | 0.454 | 0.196 | |||
| G/C | 626 (49.6%) | 261 (46.9%) | 520 (48.5%) | ||||||
| C/C | 274 (21.7%) | 120 (21.6%) | 192 (17.9%) | ||||||
| rs30187 | |||||||||
| C | 1318 (52.2%) | 589 (53.0%) | 1203 (56.1%) | 0.008 | 0.855 [0.761–0.960] | 0.678 | 0.970 [0.843–1.118] | 0.087 | 0.881 [0.762–1.019] |
| T | 1206 (47.8%) | 523 (47.0%) | 941 (43.9%) | ||||||
| C/C | 343 (27.2%) | 169 (30.4%) | 347 (32.4%) | 0.020 | 0.151 | 0.134 | |||
| C/T | 632 (50.0%) | 251 (45.1%) | 509 (47.5%) | ||||||
| T/T | 287 (22.8%) | 136 (24.5%) | 216 (20.1%) | ||||||
| rs26618 | |||||||||
| T | 1852 (73.4%) | 785 (70.6%) | 1508 (70.3%) | 0.021 | 1.162 [1.023–1.321] | 0.083 | 1.148 [0.982–1.342] | 0.879 | 1.012 [0.863–1.187] |
| C | 672 (26.6%) | 327 (29.4%) | 636 (29.7%) | ||||||
| T/T | 678 (53.7%) | 285 (51.3%) | 546 (50.9%) | 0.016 | 0.076 | 0.989 | |||
| C/T | 496 (39.3%) | 215 (38.7%) | 416 (38.8%) | ||||||
| C/C | 88 (7.0%) | 56 (10.1%) | 110 (10.3%) | ||||||
| rs26653 | |||||||||
| C | 1227 (48.6%) | 574 (51.6%) | 1143 (53.3%) | 0.001 | 0.829 [0.738–0.930] | 0.095 | 0.887 [0.770–1.021] | 0.359 | 0.934 [0.808–1.080] |
| G | 1297 (51.4%) | 538 (48.4%) | 1001 (46.7%) | ||||||
| C/C | 281 (22.3%) | 142 (25.5%) | 299 (27.9%) | 0.004 | 0.224 | 0.591 | |||
| G/C | 665 (52.7%) | 290 (52.2%) | 545 (50.8%) | ||||||
| G/G | 316 (25.0%) | 124 (22.3%) | 228 (21.3%) | ||||||
| rs3734016 | |||||||||
| C | 2159 (85.5%) | 947 (85.2%) | 1801 (84.0%) | 0.145 | 0.888 [0.756–1.041] | 0.767 | 0.970 [0.795–1.184] | 0.387 | 0.915 [0.748–1.119] |
| T | 365 (14.5%) | 165 (14.8%) | 343 (16.0%) | ||||||
| C/C | 921 (73.0%) | 404 (72.7%) | 752 (70.1%) | 0.318 | 0.832 | 0.500 | |||
| C/T | 317 (25.1%) | 139 (25.0%) | 297 (27.7%) | ||||||
| T/T | 24 (1.9%) | 13 (2.3%) | 23 (2.1%) | ||||||
Note: The statistical significant threshold was set at P < 0.0045 after Bonferroni correction