Table 4.
Inheritance model analysis of SNPs in ERAP1 gene between control and cervical cancer groups
| SNPs | Models | Genotypes | Control (Freq) | Cervical cancer (Freq) | OR[95%CI] | P-value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
| rs27037 | Condominant | G/G | 359 (28.4%) | 283 (26.4%) | 1 | 0.020 | 3218.2 | 3241.2 |
| G/T | 654 (51.8%) | 526 (49.1%) | 1.02 (0.84–1.23) | |||||
| T/T | 249 (19.8%) | 263 (24.5%) | 1.34 (1.06–1.69) | |||||
| Dominant | G/G | 359 (28.4%) | 283 (26.4%) | 1 | 0.280 | 3222.8 | 3240.1 | |
| G/T-T/T | 903 (71.6%) | 789 (73.6%) | 1.11 (0.92–1.33) | |||||
| Recessive | G/G-G/T | 1013 (80.2%) | 809 (75.5%) | 1 | 0.006 | 3216.2 | 3233.5 | |
| T/T | 249 (19.8%) | 263 (24.5%) | 1.32 (1.09–1.61) | |||||
| Log-additive | – | – | – | 1.15 (1.02–1.29) | 0.020 | 3218.6 | 3235.8 | |
| rs27044 | Condominant | G/G | 362 (28.7%) | 360 (33.6%) | 1 | 0.012 | 3217.2 | 3240.2 |
| G/C | 626 (49.6%) | 520 (48.5%) | 0.84 (0.70–1.01) | |||||
| C/C | 274 (21.7%) | 192 (17.9%) | 0.71 (0.56–0.89) | |||||
| Dominant | G/G | 362 (28.7%) | 360 (33.6%) | 1 | 0.012 | 3217.6 | 3234.9 | |
| G/C-C/C | 900 (71.3%) | 712 (66.4%) | 0.80 (0.67–0.95) | |||||
| Recessive | G/G-G/C | 988 (78.3%) | 880 (82.1%) | 1 | 0.021 | 3218.7 | 3235.9 | |
| C/C | 274 (21.7%) | 192 (17.9%) | 0.79 (0.64–0.97) | |||||
| Log-additive | – | – | – | 0.84 (0.75–0.94) | 0.003 | 3215.2 | 3232.5 | |
| rs30187 | Condominant | C/C | 343 (27.2%) | 347 (32.4%) | 1 | 0.020 | 3218.2 | 3241.2 |
| C/T | 632 (50.0%) | 509 (47.5%) | 0.80 (0.66–0.96) | |||||
| T/T | 287 (22.8%) | 216 (20.1%) | 0.74 (0.59–0.94) | |||||
| Dominant | C/C | 343 (27.2%) | 347 (32.4%) | 1 | 0.007 | 3216.6 | 3233.9 | |
| C/T-T/T | 919 (72.8%) | 725 (67.6%) | 0.78 (0.65–0.93) | |||||
| Recessive | C/C-C/T | 975 (77.2%) | 856 (79.8%) | 1 | 0.120 | 3221.6 | 3238.9 | |
| T/T | 287 (22.8%) | 216 (20.1%) | 0.86 (0.70–1.04) | |||||
| Log-additive | – | – | – | 0.86 (0.76–0.96) | 0.009 | 3217.1 | 3234.3 | |
| rs26618 | Condominant | T/T | 678 (53.7%) | 546 (50.9%) | 1 | 0.016 | 3217.7 | 3240.7 |
| C/T | 496 (39.3%) | 416 (38.8%) | 1.04 [0.88–1.24] | |||||
| C/C | 88 (7.0%) | 110 (10.3%) | 1.55 [1.15–2.10] | |||||
| Dominant | T/T | 678 (53.7%) | 546 (50.9%) | 1 | 0.180 | 3222.2 | 3239.5 | |
| C/T-C/C | 584 (46.3%) | 526 (49.1%) | 1.12 [0.95–1.32] | |||||
| Recessive | T/T-C/T | 1174 (93.0%) | 962 (89.7%) | 1 | 0.004 | 3215.9 | 3233.1 | |
| C/C | 88 (7.0%) | 110 (10.3%) | 1.53 [1.14–2.05] | |||||
| Log-additive | – | – | – | 1.16 [1.02–1.31] | 0.023 | 3218.9 | 3236.1 | |
| rs26653 | Condominant | C/C | 281 (22.3%) | 299 (27.9%) | 1 | 0.004 | 3214.8 | 3237.8 |
| C/G | 665 (52.7%) | 545 (50.8%) | 0.77 [0.63–0.94] | |||||
| G/G | 316 (25.0%) | 228 (21.3%) | 0.68 [0.54–0.86] | |||||
| Dominant | C/C | 281 (22.3%) | 299 (27.9%) | 1 | 0.002 | 3214.2 | 3231.5 | |
| C/G-G/G | 981 (77.7%) | 773 (72.1%) | 0.74 [0.61–0.89] | |||||
| Recessive | C/C-C/G | 946 (75.0%) | 844 (78.7%) | 1 | 0.034 | 3219.5 | 3236.7 | |
| G/G | 316 (25.0%) | 228 (21.3%) | 0.81 [0.67–0.98] | |||||
| Log-additive | – | – | – | 0.82 [0.73–0.93] | 0.001 | 3213.5 | 3230.7 | |
| rs3734016 | Condominant | C/C | 921 (73.0%) | 752 (70.2%) | 1 | 0.330 | 3223.8 | 3246.8 |
| C/T | 317 (25.1%) | 297 (27.7%) | 1.15 (0.95–1.38) | |||||
| T/T | 24 (1.9%) | 23 (2.1%) | 1.17 (0.65–2.09) | |||||
| Dominant | C/C | 921 (73.0%) | 752 (70.2%) | 1 | 0.140 | 3221.8 | 3239.0 | |
| C/T-T/T | 341 (27.0%) | 320 (29.9%) | 1.15 (0.96–1.37) | |||||
| Recessive | C/C-C/T | 1238 (98.1%) | 1049 (97.8%) | 1 | 0.690 | 3223.8 | 3241.1 | |
| T/T | 24 (1.9%) | 23 (2.1%) | 1.13 (0.63–2.01) | |||||
| Log-additive | – | – | – | 1.13 (0.96–1.33) | 0.150 | 3221.9 | 3239.1 |
Note: The statistical significant threshold was set at P < 0.0045 after Bonferroni correction