Table 5.
Inheritance model analysis of SNPs in ERAP2 gene between control and cervical cancer groups
| SNPs | Models | Genotypes | Control (Freq) | Cervical cancer (Freq) | OR[95%CI] | P-value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
| rs2549782 | Codominant | T/T | 395 (31.3%) | 291 (27.1%) | 1 | 0.088 | 3221.1 | 3244.2 |
| G/T | 628 (49.8%) | 564 (52.6%) | 1.22 (1.01–1.47) | |||||
| G/G | 239 (18.9%) | 217 (20.2%) | 1.23 (0.97–1.56) | |||||
| Dominant | T/T | 395 (31.3%) | 291 (27.1%) | 1 | 0.028 | 3219.2 | 3236.4 | |
| G/T-G/G | 867 (68.7%) | 781 (72.8%) | 1.22 (1.02–1.46) | |||||
| Recessive | T/T-G/T | 1023 (81.0%) | 855 (79.8%) | 1 | 0.430 | 3223.4 | 3240.6 | |
| G/G | 239 (18.9%) | 217 (20.2%) | 1.09 (0.89–1.33) | |||||
| Log-additive | – | – | – | 1.12 (1.00–1.26) | 0.057 | 3220.4 | 3237.6 | |
| rs2548538 | Condominant | T/T | 439 (34.8%) | 337 (31.4%) | 1 | 0.200 | 3222.8 | 3245.8 |
| A/T | 583 (46.2%) | 511 (47.7%) | 1.14 (0.95–1.37) | |||||
| A/A | 240 (19.0%) | 224 (20.9%) | 1.22 (0.96–1.53) | |||||
| Dominant | T/T | 439 (34.8%) | 337 (31.4%) | 1 | 0.089 | 3221.1 | 3238.4 | |
| A/T-A/A | 823 (65.2%) | 735 (68.6%) | 1.16 (0.98–1.38) | |||||
| Recessive | T/T-A/T | 1022 (81.0%) | 848 (79.1%) | 1 | 0.260 | 3222.7 | 3240.0 | |
| A/A | 240 (19.0%) | 224 (20.9%) | 1.12 (0.92–1.38) | |||||
| Log-additive | – | – | – | 1.11 (0.99–1.24) | 0.080 | 3220.9 | 3238.2 | |
| rs2248374 | Condominant | G/G | 382 (30.3%) | 269 (25.1%) | 1 | 0.020 | 3218.1 | 3241.2 |
| A/G | 632 (50.0%) | 571 (53.3%) | 1.28 (1.06–1.56) | |||||
| A/A | 248 (19.7%) | 232 (21.6%) | 1.33 (1.05–1.69) | |||||
| Dominant | G/G | 382 (30.3%) | 269 (25.1%) | 1 | 0.005 | 3216.2 | 3233.5 | |
| A/G-A/A | 880 (69.7%) | 803 (74.9%) | 1.30 (1.08–1.56) | |||||
| Recessive | G/G-A/G | 1014 (80.3%) | 840 (78.4%) | 1 | 0.230 | 3222.6 | 3239.8 | |
| A/A | 248 (19.7%) | 232 (21.6%) | 1.13 (0.92–1.38) | |||||
| Log-additive | – | – | – | 1.16 (1.03–1.31) | 0.012 | 3217.7 | 3235.0 | |
| rs2287988 | Codominant | A/A | 387 (30.7%) | 267 (24.9%) | 1 | 0.007 | 3216.0 | 3239.0 |
| A/G | 633 (50.1%) | 570 (53.2%) | 1.30 (1.07–1.58) | |||||
| G/G | 242 (19.2%) | 235 (21.9%) | 1.41 (1.11–1.78) | |||||
| Dominant | A/A | 387 (30.7%) | 267 (24.9%) | 1 | 0.002 | 3214.5 | 3231.8 | |
| A/G-G/G | 875 (69.3%) | 805 (75.1%) | 1.33 (1.11–1.60) | |||||
| Recessive | A/A-A/G | 1020 (80.8%) | 837 (78.1%) | 1 | 0.100 | 3221.3 | 3238.6 | |
| G/G | 242 (19.2%) | 235 (21.9%) | 1.18 (0.97–1.45) | |||||
| Log-additive | – | – | – | 1.19 (1.06–1.34) | 0.003 | 3215.3 | 3232.5 | |
| rs1056983 | Condominant | T/T | 439 (34.8%) | 360 (33.6%) | 1 | 0.820 | 3225.6 | 3248.6 |
| C/T | 584 (46.3%) | 505 (47.1%) | 1.06 (0.88–1.27) | |||||
| C/C | 239 (18.9%) | 207 (19.3%) | 1.06 (0.84–1.34) | |||||
| Dominant | T/T | 439 (34.8%) | 360 (33.6%) | 1 | 0.530 | 3223.6 | 3240.9 | |
| C/T-C/C | 823 (65.2%) | 712 (66.4%) | 1.06 (0.89–1.25) | |||||
| Recessive | T/T-C/T | 1023 (81.0%) | 865 (80.7%) | 1 | 0.810 | 3223.9 | 3241.2 | |
| C/C | 239 (18.9%) | 207 (19.3%) | 1.03 (0.83–1.26) | |||||
| Log-additive | – | – | – | 1.03 (0.92–1.16) | 0.580 | 3223.7 | 3241.0 |
Note: The statistical significant threshold was set at P < 0.0045 after Bonferroni correction