Table 7.
The distribution of the haplotypes constructed by SNPs in ERAP2 gene
| Haplotypes | Control (Freq) | CIN (Freq) | Cervical cancer (Freq) | Cervical cancer vs Control | CIN vs Control | Cervical cancer vs CIN | |||
|---|---|---|---|---|---|---|---|---|---|
| P-value | OR[95%CI] | P-value | OR[95%CI] | P-value | OR[95%CI] | ||||
| G-A-A-G-C | 953.78 (37.8%) | 411.75 (37.0%) | 784.87 (36.6%) | 0.219 | 1.080 [0.955–1.220] | 0.908 | 0.991 [0.852–1.153] | 0.336 | 1.079 [0.925–1.258] |
| G-A-A-G-T | 58.71 (2.3%) | 20.26 (1.8%) | 72.44 (3.4%) | 0.009 | 1.592 [1.122–2.258] | 0.053 | 1.837 [0.983–3.434] | 0.006 | 2.000 [1.215–3.292] |
| G-T-A-G-C | 61.18 (2.4%) | 25.61 (2.3%) | 71.82 (3.3%) | 0.018 | 1.513 [1.070–2.139] | 0.638 | 1.130 [0.678–1.884] | 0.055 | 1.560 [0.987–2.465] |
| T-T-G-A-T | 1346.11 (53.3%) | 586.29 (52.7%) | 973.03 (45.4%) | 0.003 | 0.835 [0.740–0.942] | 0.908 | 1.009 [0.868–1.173] | 0.009 | 0.817 [0.702–0.951] |
Note: The statistical significant threshold was set at P < 0.012 (0.05/n, n = 4) after Bonferroni correction