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PPNPs and PPNPs/GEM combination treatment disrupt plasma lipid membrane integrity in PanCa cells. Representative confocal microscopy images of PanCa cells after treatment with PBS/no treatment, blank PLGA NPs, 10 nM PTX, 100 nM GEM, 10 nM PPNPs, and 10 nM PPNPs/100 nM GEM. Membrane integrity was shown by the Deep Red plasma membrane known to stain the plasma membrane. Decrease in the intensity of the staining indicating disruption of the membrane due to treatment.
