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. 2020 Apr 13;5(15):8982–8991. doi: 10.1021/acsomega.0c00793

Figure 7.

Figure 7

Molecular effect of PPNPs and PPNPs/GEM on proteins associated with lipid membrane metabolism in PanCa cells. Cell lysates were collected after 48 h treatment with 10 nM PTX, 100 nM GEM, 10 nM PPNPs, and 10 nM PPNPs/100 nM GEM. PBS and blank PLGA NPs served as the respective control groups. Panel showing decrease in ACC, FASN, Lipin, ATP citrate lyase, Cox-2, and Bcl-2 expression and upregulation of Bax (apoptosis regulator) with PPNPs and PPNPs and GEM combination.