Table 1.

Quantitative analysis of the anticonvulsant potential of compounds TP-10, TP-315 and TP-427 in the mouse 6 Hz seizure test.

Compound	Pretreatment time [min]	ED50 ± SEM [mg/kg]	TD50 ± SEM [mg/kg]	Protective index (TD50/ED50)
	15	62.6 ± 13.2	338.1 ± 12.0	5.4
TP-10	30	61.1 ± 9.7	338.1 ± 14.7	5.5
	60	169.7 ± 18.5	333.4 ± 18.6	2.0
	120	167.6 ± 17.4	395.1 ± 25.2	2.4
	15	61.3 ± 10.1	462.9 ± 20.0	7.6
TP-315	30	59.7 ± 6.8	462.9 ± 20.0	7.8
	60	68.1 ± 11.0	456.9 ± 19.7	6.7
	120	136.2 ± 18.3	448.1 ± 21.7	3.3
	15	40.9 ± 6.4	>1000	>24.4
TP-427	30	46.6 ± 8.2	>1000	>21.5
	60	51.6 ± 6.9	540.7 ± 20.9	10.5
	120	64.9 ± 5.6	548.5 ± 21.4	8.5
Valproate	15	130.6	363.3	2.8
Levetiracetam	60	19.4	>500	>25.8

Data for levetiracetam and valproate are taken from Barton et al.²⁵ Median toxic doses (TD50) are taken from our previous papers^13–15.