Figure 4.
Exposure to predator odor decreased AMPAR-mediated currents in Bergmann glial cells. Cerebellar slices were prepared from the vermis of naive animals or stressed mice (24 h after fox urine exposure). Stimulation of parallel fibers evoked an inward current in Bergmann glial cells located in cerebellar lobule 5. Application of NBQX (10 μm) inhibits AMPA receptor-mediated currents. A, Example current traces in the presence and absence of NBQX (left) and corresponding time course of the evoked AMPAR-mediated current amplitude (right). B, Summary data of the change in current amplitude over time (naive, N = 6; stress, N = 6). C, Average current ratio (= INBQX/Itotal) shows a decrease after stress relative to control. *p < 0.005 (unpaired t test).