Figure 6.
Stress failed to reduce AMPAR-mediated currents in Bergmann glial cells in CPEB3 KO mice. Cerebellar slices were prepared 24 h after fox urine exposure or from naive CPEB3 knock-out mice. Stimulation of parallel fibers evoked an inward current in Bergmann glial cells, and the application of NBQX was used to assess the contribution of AMPARs to the total evoked current. A, Example current traces (left) and corresponding time course of the change in current amplitude (right). B, Summary data of current amplitude over time (naive, N = 5; stress, N = 5). C, Average current ratio (INBQX/Itotal) remains unaltered after stress relative to control.