Table 3.
Coefficients of canonical variables from MANOVA of vPMC layer 3 pyramidal neuron properties
| Electrophysiological properties | |||||
|---|---|---|---|---|---|
| Outcome variables | coeff1 (p = 0.0000006) | abs(coeff1) | Outcome variables | coeff2 (p = 0.04) | abs(coeff2) |
| AP firing frequency (60 pA) | 3.14 | 3.14 | AP firing frequency (40 pA) | −2.6 | 2.6 |
| AP firing frequency (80 pA) | −1.84 | 1.84 | AP fall time | 1.91 | 1.91 |
| EPSC frequency | −1.33 | 1.33 | AP firing frequency (60 pA) | 1.85 | 1.85 |
| AP firing frequency (40 pA) | −1.09 | 1.09 | AP firing frequency (20 pA) | 1.4 | 1.4 |
| IPSC frequency | 0.83 | 0.83 | AP duration | −0.83 | 0.83 |
| Rheobase | −0.52 | 0.52 | EPSC amplitude | 0.68 | 0.68 |
| AP amplitude | 0.46 | 0.46 | IPSC frequency | −0.51 | 0.51 |
| AP rise time | −0.37 | 0.37 | AP threshold | −0.43 | 0.43 |
| EPSC total charge | 0.32 | 0.32 | AP amplitude | −0.38 | 0.38 |
| AP threshold | 0.28 | 0.28 | FFA(late) | −0.31 | 0.31 |
| AP fall time | 0.26 | 0.26 | EPSC total charge | 0.25 | 0.25 |
| AP duration | −0.26 | 0.26 | AP rise time | −0.24 | 0.24 |
| AP firing frequency (20 pA) | 0.25 | 0.25 | AP firing frequency (80 pA) | −0.24 | 0.24 |
| FFA (late) | −0.23 | 0.23 | Rheobase | 0.2 | 0.2 |
| E:I ratio | 0.2 | 0.2 | EPSC frequency | 0.1 | 0.1 |
| FFA (initial) | 0.03 | 0.03 | FFA (initial) | −0.1 | 0.1 |
| EPSC amplitude | 0.01 | 0.01 | E:I ratio | −0.05 | 0.05 |
| Morphologic properties | |||||
| Outcome variables | coeff1 (p = 0.01) | abs(coeff1) | Outcome variables | coeff2 (p = 0.52) | abs(coeff2) |
| Apical nodes | −65.0 | 65.0 | Apical L | 15.7 | 15.7 |
| Apical oblique nodes | 45.6 | 45.6 | Apical oblique L | −9.7 | 9.7 |
| Apical tuft nodes | 34.1 | 34.1 | Apical tuft L | −9.7 | 9.7 |
| Apical oblique L | −28.4 | 28.4 | Apical tuft L | −6.4 | 6.4 |
| Apical L | 26.7 | 26.7 | Apical oblique nodes | 5.7 | 5.7 |
| No. of obliques | 20.0 | 20.0 | Apical tuft nodes | 4.1 | 4.1 |
| Apical tuft L | −15.8 | 15.8 | Basal VGAT density on spines | 2.5 | 2.5 |
| Basal hor extent | 9.7 | 9.7 | Apical spine density | 1.5 | 1.5 |
| Basal nodes | 8.7 | 8.7 | VGAT density on soma | 1.5 | 1.5 |
| Basal VGAT density on spines | −7.3 | 7.3 | Basal spine density | −1.4 | 1.4 |
| Basal VGAT density on shaft | 6.5 | 6.5 | Basal ver extent | −1.2 | 1.2 |
| Basal L | −6.3 | 6.3 | Basal hor extent | −1.1 | 1.1 |
| Apical VGAT density on spines | 6.0 | 6.0 | Basal nodes | −1.1 | 1.1 |
| Apical ver extent | −5.4 | 5.4 | Apical trunk L | 1.0 | 1.0 |
| Apical trunk L | 3.1 | 3.1 | Basal L | 1.0 | 1.0 |
| Apical tuft hor extent | −2.0 | 2.0 | Apical ver extent | 0.9 | 0.9 |
| Apical VGAT density on shaft | −1.7 | 1.7 | Basal VGAT density on shaft | −0.7 | 0.7 |
| Basal ver extent | 1.7 | 1.7 | No. of obliques | −0.6 | 0.6 |
| Apical spine density | −0.7 | 0.7 | Apical tuft hor extent | 0.5 | 0.5 |
| Basal spine density | 0.7 | 0.7 | Apical VGAT density on spines | −0.4 | 0.4 |
| VGAT density on soma | 0.6 | 0.6 | Apical VGAT density on shaft | 0.2 | 0.2 |