Table 2.
High throughput multiplex analysis of biomarkers selected by supervised multivariate principal component analysis. Plasma concentrations of the assessed proteins are expressed on a log2-scale. Inter-group differences were assessed using analysis of variance method. *Bonferroni-corrected significant values (p < 0.0022)
| Biomarker | POTS+ (n = 113) |
POTS- (n = 283) |
P-value* |
|---|---|---|---|
| TIM | 4.32 (0.08) | 4.49 (0.05) | 0.078 |
| PSGL1 | 0.69 (0.04) | 0.8 (0.02) | 0.009 |
| CTSL1 | 5.3 (0.04) | 5.46 (0.03) | 0.004 |
| MB | 4.86 (0.07) | 5.14 (0.06) | 0.0020* |
| VEGFD | 6.7 (0.06) | 6.82 (0.03) | 0.062 |
| PlGF | 7.1 (0.05) | 7.21 (0.04) | 0.131 |
| MMP1 | 3.04 (0.14) | 3.41 (0.09) | 0.029 |
| GDF15 | 8.22 (0.07) | 8.42 (0.05) | 0.058 |
| FAS | 6.93 (0.04) | 7.02 (0.03) | 0.045 |
| TF | 5.53 (0.04) | 5.61 (0.03) | 0.120 |
| AM | 5.83 (0.09) | 6.05 (0.05) | 0.029 |
| UPAR | 9.66 (0.03) | 9.72 (0.03) | 0.127 |
| TNFR2 | 4.82 (0.04) | 4.9 (0.03) | 0.116 |
| TRAIL | 8.44 (0.04) | 8.52 (0.03) | 0.183 |
| MCP1 | 3.07 (0.05) | 3.24 (0.05) | 0.014 |
| TRAILR2 | 1.21 (0.03) | 1.28 (0.02) | 0.080 |
| OPG | 9.16 (0.04) | 9.25 (0.03) | 0.095 |
| CASP8 | 1.45 (0.07) | 1.33 (0.05) | 0.126 |
| HGF | 6.22 (0.04) | 6.34 (0.04) | 0.030 |
| CD40L | 8.57 (0.11) | 8.6 (0.07) | 0.647 |
| GH | 9.37 (0.26) | 8.37 (0.2) | 0.0019* |
| PTX3 | 1.38 (0.06) | 1.28 (0.04) | 0.124 |
| SRC | 7.66 (0.07) | 7.77 (0.03) | 0.087 |