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. 2020 Apr 22;21:97. doi: 10.1186/s12931-020-01362-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Lung histopathology accentuated with rechallenge following a 4 week recovery after repetitive ODE exposure. WT and MyD88 KO mice were repetitively exposed to saline or ODE for 3 weeks followed by a 4 week rest/recovery phase and then subsequently re-challenge once with saline or ODE. Panel a, Lung sections (5 μm) were H&E stained with representative images shown from each group of 4 animals/group (scale denotes 100 μm; 2x magnification). Arrows denote lymphocytic aggregates. Panel b, Confocal images of lung tissues stained for B cells (CD45.R; green) and macrophages (CD68; blue) shown at 40x magnification with selected images focused on aggregates where available. Scatter dot plots demonstrate mean with standard error bars of mean pixel density representing two regions of interest (ROIs) from each mouse (N = 8 ROI/group) depicting CD45.R⁺ B cells c and CD68⁺ Macrophages d. Treatment groups denoted as S-S (saline repeated exposure-saline rechallenge), O-S (ODE repeated exposure-saline rechallenge), S-O (saline repeated exposure-ODE rechallenge), and O-O (ODE repeated exposure-ODE rechallenge). Statistical significance denoted as ##p < 0.01, ###p < 0.001 vs. WT-S-S; and **p < 0.01, ***p < 0.001 denoted between groups (line)