Table 4.

Regions in which seed-based resting functional connectivity strengths were significantly different between CRPS patients and healthy controls. Note that “seed” clusters were derived from the previous gray matter volume analyses. Locations are in Montreal Neurological Institute space. Significant clusters were formed with cluster-extent thresholding (family-wise error rate) to correct for multiple comparisons.

	X	Y	Z	z-statistic	cluster	cluster size	p-value
crps > controls
seed: right putamen
right primary somatosensory cortex	20	−54	64	3.94	1	1545	0.00061
right superior parietal lobe	12	−50	50	3.86
crps < controls
seed: right putamen
right cerebellum crus1	4.48	40	−52	−32	1	1448	0.00099
pain intensity (positive) correlation
seed: left putamen
right primary somatosensory	34	−32	60	3.15	1	735	0.02720
right primary motor cortex	32	−24	54	3.49
dystonia (positive) correlation
seed: left putamen
left supramarginal gyrus	−52	−46	24	3.40	1	892	0.01010
Hand coordination, crps > controls
seed: left putamen
left postcentral gyrus	−67	−15	20	4.45	1	992	0.00339
left supramarginal gyrus	−64	−40	17	3.83
right premotor cortex	48	2	14	4.11	2	1482	0.00069
right precentral gyrus	58	−8	34	3.64
right postcentral gyrus	66	−18	20	3.60
Hand coordination, crps < controls
seed: left putamen
left precuneus	−10	−84	52	4.27	1	1893	0.00000
left lateral occipital cortex	−30	−80	32	5.39
right cerebellum crus I	42	−74	−28	3.39	2	784	0.03320
right cerebellum crus II	48	−70	−42	3.24
Forearm range of motion, crps < controls
seed: right putamen
left precentral gyrus	−60	−4	14	3.80	1	907	0.01620
left postcentral gyrus	−50	−16	18	4.34