Table 4.

Comparison of the MTT assay anticancer results of chalcones (17–31) and dihydropyrazoles (32–46) (IC₅₀ values in µg/mL).

Compound	DU-145	Human Normal Cells (L02)	Compound	DU-145	Human Normal Cells (L02)
17	32 ± 2	>40	32	28 ± 1	>40
18	20 ± 1	>40	33	18 ± 2	>40
19	36 ± 1	>40	34	32 ± 2	>40
20	22 ± 1	>40	35	16 ± 2	>40
21	29 ± 2	>40	36	26 ± 2	>40
22	38 ± 1	>40	37	31 ± 2	>40
23	33 ± 2	>40	38	20 ± 2	>40
24	6 ± 2	>40	39	4 ± 2	>40
25	12 ± 1	>40	40	8 ± 2	>40
26	10 ± 2	>40	41	9 ± 1	>40
27	26 ± 3	>40	42	18 ±2	>40
28	30 ± 2	>40	43	21 ± 2	>40
29	8 ± 2	>40	44	5 ± 2	>40
30	5 ± 2	>40	45	2 ± 1	>40
31	16 ±2	>40	46	12 ± 2	>40
Docetaxel 5 ± 1

Data presented as mean ± SD (n = 3). All the compounds and the standard dissolved in DMSO, diluted with culture medium containing 0.1% DMSO. The control cells were treated with culture medium containing 0.1% DMSO.