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. 2020 Feb 25;25(5):1018. doi: 10.3390/molecules25051018

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Kinetic modeling results with [¹¹C]CW24 in the macaque brain. (A) The total volume of distribution (V_T) images derived from Logan plot with arterial blood data as input function (color bar indicates V_T values from 1–2.5 mL/cm³ (blue to red); (B) Regional V_T values showed that the expression difference in brain regions; (C) Arterial plasma analysis showed that [¹¹C]CW24 radioactivity was rapidly cleared from blood and [¹¹C]CW24 stability evaluated in plasma over time showed lasting presence of ~47% of parent compound at 30 min.