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. 2020 Feb 26;25(5):1054. doi: 10.3390/molecules25051054

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of SG-1, SG-2 or T1AM treatment on the expression of autophagy ATG target genes in U87MG cells. After 24h incubation of U87MG cells with 1μM SG-1, SG-2 or T1AM total RNA was extracted, and the relative mRNA quantification of Sirt6 (a), Hif1α (b), or p53 and mTOR (c) was performed by real-time RT-PCR. The data are expressed as fold changes vs control and represent the mean ± SEM of three different experiments (n = 3), each performed in duplicate. Statistical significance was determined using a one-way ANOVA followed by a Dunnett’s post-test: * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.005 vs control.

Effect of SG-1, SG-2 or T1AM treatment on the expression of autophagy ATG target genes in U87MG cells. After 24h incubation of U87MG cells with 1μM SG-1, SG-2 or T1AM total RNA was extracted, and the relative mRNA quantification of Sirt6 (a), Hif1α (b), or p53 and mTOR (c) was performed by real-time RT-PCR. The data are expressed as fold changes vs control and represent the mean ± SEM of three different experiments (n = 3), each performed in duplicate. Statistical significance was determined using a one-way ANOVA followed by a Dunnett’s post-test: * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.005 vs control.