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. 2020 Feb 26;25(5):1054. doi: 10.3390/molecules25051054

Figure 7.

Figure 7

SG2 rescues LTP expression in the EC superficial layer of mhAPP mice. The LTP was induced by HFS stimulation in non-transgenic slices under ACSF (nontg + vehicle, white diamonds), whereas LTP expression was not elicited by HFS in mhAPP slices perfused with ACSF (mhAPP + vehicle, white circle) (n = 7). Perfusion of SG2 5μM (5μM, black circles, 10 min of application corresponding to the dark bar) rescued LTP expression in mhAPP slices (n = 6), whereas a lower concentration of SG2 (1μM, grey circles, 10 min of application corresponding to the dark bar) had no significant effect on mhAPP slices after HFS (n = 9). Error bars indicate SEM. Insert shows representative field potentials recorded either before or 35 min after HFS, in mhAPP slices under ACSF (mhAPP + vehicle, left) and in mhAPP slices under SG2 5μM (mhAPP+SG2 5μM, right). Calibration bars: 1 mV, 5 ms.