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Example of midazolam control of PTZ-induced convulsion activity. The animal received an ED50 dose of MDZ/S or MDZ/NCs. (A) Gradually occurring convulsions. (B) Convulsions induced by PTZ. (C) The convulsion activity gradually stopped. (D) EEG after death of the animal. Calibration: 0.5 mV, 5 sec. Abbreviations: PTZ, pentylenetetrazole; EEG, electroencephalogram.
