Table 5.

Pharmacokinetic parameters of MDZ/NCs-A and MDZ solution after intramuscular administration at a dose of 1.0 mg/kg in Sprague–Dawley rats (n = 6).

Parameters	Unit	MDZ/NCs	MDZ/S
T1/2	h	1.67 ± 0.46	1.48 ± 0.60
Tmax	h	0.15 ± 0.17	0.09 ± 0.04
Cmax	ng/mL	797.20 ± 236.88	805.62 ± 204.71
AUC(0-t)	h·ng/mL	581.69 ± 225.05 **	217.01 ± 79.12
AUC(0-∞)	h·ng/mL	591.46 ± 219.16 **	219.82 ± 78.59
V	mL	1392.24 ± 656.24	3279.63 ± 1708.20
CL	mL/h	563.02 ± 213.52 **	1545.07 ± 662.59
MRT(0-t)	h	2.16 ± 0.74 **	0.69 ± 0.19
MRT(0-∞)	h	2.50 ± 0.72 **	0.89 ± 0.34

Note: The data represent the mean ± SD (n = 6) (** p < 0.01) compared with the same treatment dose in the MDZ/NC model group. Abbreviations: CL, clearance; MRT, mean residence time; AUC_(0–t), area under the curve from time of administration to time “t”; AUC_(0–∞), area under the curve from time of administration through infinite time; V, apparent distribution volume; C_max, peak plasma concentration.