Table 4.

Selected physicochemical and pharmacokinetic properties of the analyzed compounds.

Comp. Name/CSD Ref. Code	iLog P	Molar Refractivity	Log S	WLOGP	TPSA [Ǻ2]	In Silico% Absorption	GI Absorption	P-gp Substrate	Log Kp
DFMO	0.53	38.28	S	0.61	89.34	78.17	high	no	−9.48
1	2.30	98.96	MS	1.44	115.73	69.08	high	no	−7.39
EXOFAY	0.00	128.51	S	−0.42	112.50	70.19	high	yes	−7.90
GOTFAY	−2.81	88.26	S	−1.19	247.11	23.75	low	no	−10.55
TEFMIA	0.64	88.89	S	0.83	253.10	21.69	low	no	−10.11
2	0.00	39.76	S	−6.63	95.41	76.09	low	no	−9.89
ORNBDL10	0.00	42.84	S	−6.63	95.41	76.09	low	no	−10.04
BAPKUB	0.00	55.30	S	−5.55	181.22	46.48	low	yes	−13.23
BAPKOV	0.00	52.22	S	−5.55	181.22	46.48	low	yes	−13.08
EVIJAU	0.00	64.75	S	−5.27	250.10	22.72	low	yes	−13.34
BEZQOO	0.00	51.30	S	2.30	101.81	73.88	high	no	−9.20
YIGMAE	0.00	46.31	S	1.03	95.41	76.09	high	no	−8.75
IHEPES	0.00	58.60	S	−1.66	89.19	78.23	high	no	−7.81
VUYHII	0.42	61.92	S	−8.21	212.54	35.68	low	yes	−15.30
CAPRAM	0.42	61.92	S	−8.21	212.54	35.68	low	yes	−15.30
BIHYEX	−0.97	49.42	S	−2.62	190.45	43.30	low	yes	−13.88
BAPKIP	−1.31	58.90	S	−2.27	250.10	22.72	low	yes	−13.69
JADGED	0.06	61.86	S	−5.46	189.91	43.49	low	yes	−12.80
PUYVUA	0.69	46.44	S	−3.35	164.29	52.32	low	no	−10.50

iLogP – liphophilicity; Log S – water solubility (SILICOS-IT; S-soluble, MS-moderately soluble); TPSA – topological polar surface area [Ǻ²]; in silico % absorption = 109 – (0.345 x TPSA); GI – gastro intestinal absorption; P-gp – p-glycoprotein inhibitors; Log Kp – skin permeability coefficient (Kp in cm/s).