Table 3.
Main pharmacokinetic parameters of FITC-fucoidan in mice tissues by intravenous administration (50 mg/kg).
| Parameter | Unit | Tissue | ||||
|---|---|---|---|---|---|---|
| Blood | Liver | Spleen | Lung | Kidney | ||
| Kel | 1/h | 0.25 ± 0.10 | 0.07 ± 0.01 | 0.003 ± 0.02 | 0.18 ± 0.05 | 0.03 ± 0.04 |
| T1/2 | h | 2.77 ± 0.82 | 10.67 ± 3.73 | 209.22 ± 6.94 | 3.79 ± 0.97 | 22.27 ± 1.75 |
| Tmax | h | 0.5 | 0.5 ± 0.29 | 6 ± 1.15 | 4 ± 1 | 0.5 |
| Cmax | μg/g | 66.37 ± 25.56 | 284.27 ± 211.88 | 77.79 ± 30.05 | 110.92 ± 81.897 | 1092.31 ± 297.66 |
| C0 | μg/g | 135.28 ± 59.91 | 495.25 ± 159.14 | 47.61 ± 17.28 | 188.58 ± 48.32 | 1949.94 ± 1448.45 |
| AUC 0-t | μg/g×h | 138.71 ± 20.64 | 1653.86 ± 567.04 | 1597.28 ± 394.38 | 1694.21 ± 580.70 | 7520.11 ± 2110.44 |
| AUC 0-∞ | μg/g×h | 198.11 ± 41.10 | 2947.506 ± 992.52 | 22886.97 ± 1301.13 | 1709.85 ± 588.22 | 12834.30 ± 5247.13 |
| MRT 0-∞ | h | 3.23 ± 1.30 | 14.66 ± 5.94 | 303.96 ± 13.44 | 6.88 ± 0.37 | 28.14 ± 12.324 |
| CL | (mg)/(μg/g)/h | 0.25 ± 0.04 | 0.02 ± 0.001 | 0.002 ± 0.01 | 0.03 ± 0.004 | 0.004 ± 0.003 |