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. 2020 Feb 29;25(5):1092. doi: 10.3390/molecules25051092

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Illustrative drawing representing the multidimensional configuration, including the extraction column (first dimension) connected to the analytical column (second dimension) via a switching valve placed before the HPLC-MS/MS instrument.