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. 2020 Feb 25;25(5):1022. doi: 10.3390/molecules25051022

Figure 4.

Figure 4

MiR-155 suppressed suppressor of cytokine signaling 1 (SOCS-1) in lung tissues and neutrophils. (A,B) MiR-155–/– mice were smoke-exposed for 15 min and sacrificed after 12 h, following which SOCS-1 mRNA and protein level of whole lung homogenates were measured. Neutrophils were isolated from lung tissues after 12 h following smoke exposure, and isolated neutrophils were treated with smoke for 30 min. (C,D) After 24 h of culture, SOCS-1 mRNA and protein level of isolated neutrophils were analyzed. n = 4 mice per group. *p < 0.05 vs. WT mice treated with smoke.