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. Author manuscript; available in PMC: 2020 Apr 23.
Published in final edited form as: Cell Rep. 2020 Feb 18;30(7):2209–2224.e5. doi: 10.1016/j.celrep.2020.01.064

Figure 4. TLR2 Deficiency Protects against NaIO3-Induced Photoreceptor Cell Death and Complement Factor C3 Deposition.

Figure 4.

(A–C) WT and TLR2–/– mice were injected IV, with NaCl or NaIO3 (50 mg/kg) and eyes enucleated 72 h later.

(A) TUNEL (red) immunoreactivity (scale bars represent 20 µm) and (B) TUNEL quantification.

(C) Number of photoreceptor cell rows in the ONL. Data shown are mean ± SEM; p value determined by nonparametric t test.

(D and E) IF of C3 in (D) WT versus (E) TLR2–/– mice.

(F and G) Expression of C3 cleavage fragments in RPE/choroid tissue from WT and TLR2–/– mice injected i.v., with NaCl or NaIO3 (F) representative images and (G) quantification of iC3b.

*p < 0.05,**p < 0.01, ***p < 0.001.