TABLE 2.
Antimicrobial activity of rezafungin tested against the main organisms and organism groups from all years using the CLSI method
| Organism/organism group (no. of isolates) | No. (cumulative %) of isolates inhibited at MIC (μg/ml) ofa: |
MIC (μg/ml) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.002 | 0.004 | 0.008 | 0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | >b | 50% | 90% | |
| Candida albicans (835) | 11 (3.8) | 6 (5.8) | 87 (10.4) | 270 (42.8) | 309 (79.8) | 139 (96.4) | 28 (99.8) | 2 (100.0) | 0.03 | 0.06 | |||||
| 2016 (276) | 13 (4.7) | 100 (40.9) | 113 (81.9) | 38 (95.7) | 11 (99.6) | 1 (100.0) | 0.03 | 0.06 | |||||||
| 2017 (267) | 12 (4.5) | 83 (35.6) | 96 (71.5) | 66 (96.3) | 10 (100.0) | 0.03 | 0.06 | ||||||||
| 2018 (292) | 11 (3.8) | 6 (5.8) | 45 (21.2) | 87 (51.0) | 100 (85.3) | 35 (97.3) | 7 (99.7) | 1 (100.0) | 0.015 | 0.06 | |||||
| Candida glabrata (374) | 1 (0.3) | 0 (0.3) | 0 (0.3) | 5 (1.6) | 136 (38.0) | 162 (81.3) | 54 (95.7) | 6 (97.3) | 3 (98.1) | 3 (98.9) | 4 (100.0) | 0.06 | 0.12 | ||
| 2016 (135) | 0 (0.0) | 1 (0.7) | 38 (28.9) | 65 (77.0) | 27 (97.0) | 3 (99.3) | 0 (99.3) | 0 (99.3) | 1 (100.0) | 0.06 | 0.12 | ||||
| 2017 (121) | 0 (0.0) | 33 (27.3) | 60 (76.9) | 20 (93.4) | 2 (95.0) | 3 (97.5) | 2 (99.2) | 1 (100.0) | 0.06 | 0.12 | |||||
| 2018 (118) | 1 (0.8) | 0 (0.8) | 0 (0.8) | 4 (4.2) | 65 (59.3) | 37 (90.7) | 7 (96.6) | 1 (97.5) | 0 (97.5) | 1 (98.3) | 2 (100.0) | 0.03 | 0.06 | ||
| Candida parapsilosis (329) | 0 (0.0) | 1 (0.3) | 0 (0.3) | 0 (0.3) | 1 (0.6) | 5 (2.1) | 62 (21.0) | 134 (61.7 | 124 (99.4) | 2 (100.0) | 1 | 2 | |||
| 2016 (94) | 0 (0.0) | 2 (2.1) | 13 (16.0) | 37 (55.3) | 42 (100.0) | 1 | 2 | ||||||||
| 2017 (118) | 0 (0.0) | 1 (0.8) | 0 (0.8) | 0 (0.8) | 0 (0.8) | 2 (2.5) | 14 (14.4) | 48 (55.1) | 51 (98.3) | 2 (100.0) | 1 | 2 | |||
| 2018 (117) | 0 (0.0) | 1 (0.9) | 1 (1.7) | 35 (31.6) | 49 (73.5) | 31 (100.0) | 1 | 2 | |||||||
| Candida tropicalis (196) | 12 (6.1) | 52 (32.7) | 75 (70.9) | 41 (91.8) | 11 (97.4) | 3 (99.0) | 0 (99.0) | 1 (99.5) | 1 (100.0) | 0.03 | 0.06 | ||||
| 2016 (64) | 3 (4.7) | 20 (35.9) | 24 (73.4) | 12 (92.2) | 3 (96.9) | 0 (96.9) | 0 (96.9) | 1 (98.4) | 1 (100.0) | 0.03 | 0.06 | ||||
| 2017 (54) | 0 (0.0) | 11 (20.4) | 19 (55.6) | 17 (87.0) | 5 (96.3) | 2 (100.00) | 0.03 | 0.12 | |||||||
| 2018 (78) | 0 (0.0) | 9 (11.5) | 21 (38.5) | 32 (79.5) | 12 (94.9) | 3 (98.7) | 1 (100.0) | 0.03 | 0.06 | ||||||
| Candida krusei (77) | 0 (0.0) | 22 (28.6) | 31 (68.8) | 17 (90.9) | 7 (100.0) | 0.03 | 0.06 | ||||||||
| 2016 (33) | 0 (0.0) | 8 (24.2) | 17 (75.8) | 7 (97.0) | 1 (100.0) | 0.03 | 0.06 | ||||||||
| 2017 (28) | 0 (0.0) | 3 (10.7) | 12 (53.6) | 10 (89.3) | 3 (100.0) | 0.03 | 0.12 | ||||||||
| 2018 (16) | 0 (0.0) | 11 (68.8) | 2 (81.2) | 0 (81.2) | 3 (100.0) | 0.015 | 0.12 | ||||||||
| Candida dubliniensis (93) | 1 (1.1) | 0 (1.1) | 1 (2.2) | 4 (6.5) | 30 (38.7) | 39 (80.6) | 18 (100.0) | 0.06 | 0.12 | ||||||
| 2016 (30) | 0 (0.0) | 8 (26.7) | 15 (76.7) | 7 (100.0) | 0.06 | 0.12 | |||||||||
| 2017 (28) | 0 (0.0) | 1 (3.6) | 9 (35.7) | 11 (75.0) | 7 (100.0) | 0.06 | 0.12 | ||||||||
| 2018 (35) | 1 (2.9) | 0 (2.9) | 1 (5.7) | 3 (14.3) | 13 (51.4) | 13 (88.6) | 4 (100.0) | 0.03 | 0.12 | ||||||
| Cryptococcus neoformans var. grubii (73) | 0 (0.0) | 9 (12.3) | 64 (100.0) | >4 | >4 | ||||||||||
| 2016 (27) | 0 (0.0) | 27 (100.0) | >4 | >4 | |||||||||||
| 2017 (25) | 0 (0.0) | 7 (28.0) | 18 (100.0) | >4 | >4 | ||||||||||
| 2018 (21) | 0 (0.0) | 2 (9.5) | 19 (100.0) | >4 | >4 | ||||||||||
| Aspergillus fumigatus (183) | 3 (4.0) | 64 (36.6) | 88 (84.7) | 28 (100.0) | 0.015 | 0.03 | |||||||||
| 2016 (48) | 26 (54.2) | 20 (95.8) | 2 (100.0) | ≤0.008 | 0.015 | ||||||||||
| 2017 (60) | 25 (41.7) | 29 (90.0) | 6 (100.0) | 0.015 | 0.015 | ||||||||||
| 2018 (75) | 0 (0.0) | 3 (4.0) | 13 (21.3) | 39 (73.3) | 20 (100.0) | 0.015 | 0.03 | ||||||||
| Aspergillus section Flavi (45) | 5 (33.3) | 20 (55.6) | 18 (95.6) | 2 (100.0) | ≤0.008 | 0.015 | |||||||||
| 2016 (12) | 3 (25.0) | 7 (83.3) | 2 (100.0) | 0.015 | 0.03 | ||||||||||
| 2017 (18) | 8 (44.4) | 10 (100.0) | 0.015 | 0.015 | |||||||||||
| 2018 (15) | 0 (0.0) | 5 (33.3) | 9 (93.3) | 1 (100.0) | 0.008 | 0.008 | |||||||||
a
During the 2016 and 2017 study years, the lowest echinocandins concentration tested was 0.008 μg/ml. The range was expanded to 0.002 μg/ml in 2018.
b
>, greater than the last concentration tested.