TABLE 4.

Summary of fks alterations detected in Candida strains as part of the 2016 to 2018 rezafungin surveillance program^a

Isolate	Country	Yr	Organism	MIC (μg/ml) by CLSI method				1,3-β-d-Glucan synthase mutation in:
				RFG	AFG	CAS	MFG	fks1 HS1	fks1 HS2	fks2 HS1	fks2 HS2
1051621	Hungary	2018	C. tropicalis	0.25	0.25	0.12	0.12	WT	WT	NT	NT
1051641	Hungary	2018	C. glabrata	1	1	1	0.5	WT	WT	F659_del	WT
1053234	Canada	2018	C. glabrata	0.12	0.12	0.06	0.06	WT	WT	WT	WT
1075570	Belgium	2018	C. glabrata	0.06	0.12	0.06	0.06	WT	WT	WT	WT
1078854	USA	2018	C. glabrata	0.06	0.06	0.06	0.06	WT	WT	F659_del	WT
1078861	USA	2018	C. glabrata	2	2	1	1	WT	WT	S663P	WT
1085740	Spain	2018	C. tropicalis	0.06	0.06	0.06	0.12	WT	WT	NT	NT
1087598	USA	2018	C. glabrata	2	4	4	4	WT	WT	S663P	WT
997524	Mexico	2017	C. glabrata	0.5	0.5	0.25	0.06	F625S	WT	WT	WT
999721	Italy	2017	C. glabrata	0.06	0.06	0.06	0.06	WT	WT	WT	WT
1015009	Spain	2017	C. glabrata	0.5	1	0.5	0.25	WT	WT	Y657 deletion, F658Y	WT
1020535	USA	2017	C. glabrata	0.25	0.25	0.12	0.06	WT	WT	WT	WT
1021070	France	2017	C. glabrata	1	2	0.5	0.5	WT	WT	S663P	WT
1025460	USA	2017	C. glabrata	0.5	1	0.5	1	S629P	WT	R665G	WT
1026179	Spain	2017	C. glabrata	1	1	0.25	0.25	WT	WT	Y657 deletion, F658Y	WT
1034513	Ireland	2017	C. glabrata	2	4	2	0.5	WT	WT	S663P	WT
1034514	Ireland	2017	C. glabrata	0.25	0.5	0.12	0.12	WT	WT	S663P	WT
1034803	USA	2017	C. glabrata	0.12	0.12	0.06	0.06	WT	WT	WT	WT
1034763	Turkey	2017	C. tropicalis	0.06	0.06	0.25	0.12	WT	WT	NT	NT
1034766	Turkey	2017	C. tropicalis	0.12	0.25	0.03	0.06	WT	WT	NT	NT
1041544	Greece	2017	C. tropicalis	0.06	0.06	0.03	0.12	WT	WT	NT	NT
984357	Ireland	2016	C. albicans	0.25	0.12	1	1	S645P	WT	NT	NT
978825	Turkey	2016	C. albicans	0.12	0.12	0.12	0.06	WT	WT	NT	NT
948247	USA	2016	C. glabrata	0.06	0.12	0.03	0.03	WT	WT	WT	WT
949151	USA	2016	C. glabrata	0.03	0.06	0.06	0.12	WT	WT	WT	WT
970382	USA	2016	C. glabrata	0.25	0.25	0.12	0.12	S629P	WT	WT	WT
970397	USA	2016	C. glabrata	0.12	0.25	0.25	0.12	WT	WT	P667H	WT
974239	USA	2016	C. glabrata	0.25	0.25	0.06	0.12	S629P	WT	WT	WT
974249	USA	2016	C. glabrata	2	2	1	1	WT	WT	S663P	WT
978819	Turkey	2016	C. glabrata	0.25	0.25	0.06	0.06	WT	WT	WT	WT
983007	USA	2016	C. glabrata	0.12	0.5	0.06	0.12	WT	WT	F658_del	WT
985673	USA	2016	C. glabrata	0.06	0.12	0.06	0.06	WT	WT	S663P	WT
936285	Germany	2016	C. krusei	0.12	0.12	0.25	0.12	WT	WT	NT	NT
954660	Italy	2016	C. krusei	0.015	0.03	0.06	0.06	WT	WT	NT	NT
975699	USA	2016	C. krusei	0.015	0.06	0.12	0.06	WT	WT	NT	NT
977046	Brazil	2016	C. krusei	0.015	0.015	0.06	0.06	WT	WT	NT	NT
970388	USA	2016	C. tropicalis	2	1	>8	2	S654P	WT	NT	NT
977041	Brazil	2016	C. tropicalis	1	1	2	1	F650S	WT	NT	NT

^aRFG, rezafungin; AFG, anidulafungin; CAS, caspofungin; MFG, micafungin; WT, wild type; NT, not tested.