Circular maps of IncA plasmids. Circular maps of (starting from the inner circle) IncA reference plasmid pRA1 from Aeromonas hydrophila (NC_012885.1), plasmid pFDL_VIM from Klebsiella oxytoca of patient 1, pGA_VIM from Escherichia coli of patient 1, and pGB_VIM Enterobacter cloacae from patient 2. Colored arrows represent the blaVIM-1 gene (turquoise), conjugal transfer system (green), resistance genes (red), mobile elements (yellow), hypothetical proteins (plum), replication protein repA (orange), and virulence region identified only in pGB-VIM plasmids from patient 2 (bright green).