FIG 2.

CoPP treatment does not induce inflammatory cytokines in the lungs during Y. pestis infection. Groups of five male and female C57BL/6 mice were treated as described for Fig. 1 with vehicle (open circles) or CoPP (closed circles) and challenged with Y. pestis CO92. At 48 hpi, the lungs were removed, homogenized in PBS, and analyzed for HO-1 (A), IL-6 (B), TNF-α (C), and IFN-γ (D) by ELISA. The data shown are combined from four independent trials (n = 20 per group). The data were analyzed by one-way ANOVA with Tukey’s posttest (*, P < 0.05; ***, P < 0.001). The bars indicate the median. nd, not detected.