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Cross-resistance of FHNA-resistant and other mutants against mycophenolic acid and 6-azauridinea
| rCHIKV | Mycophenolic acid |
6-Azauridine |
||
|---|---|---|---|---|
| Mean EC50 (μM) ± SD | Fold resistance | EC50 (μM) ± SD | Fold resistance | |
| wt | 0.4 ± 0.01 | 1 | 0.3 ± 0.01 | 1 |
| R171Q | 4.2 ± 2.8 | 11 | 0.8 ± 0.1 | 3 |
| *524R | 6.3 ± 11.4 | 16 | 8.9 ± 3.4 | 30 |
| G230R+K299E | 1.1 ± 0.5 | 3 | 1.1 ± 0.1 | 4 |
| G230R+K299E+*524R | 0.5 ± 0.03 | 1 | 0.9 ± 0.1 | 4 |
The fold resistance = (EC50 recombinant mutant/EC50 wt).
