FIG 2.

Schematic of the final model, linking the antibiotic concentration-time course (C_AB) to the bacterial dynamics represented by the S (susceptible), R (resting), and F (filament) states, with the antibiotic stimulating killing of the S (and F) population(s) through a sigmoidal Emax relationship to cefuroxime exposure (C_AB). The increase in the LPS/endotoxin concentration (C_ETX) was driven by the growth of the bacteria in S (direct contribution to C_ETX) and by the antibiotic-induced killing of bacteria in S and F (delayed contribution to C_ETX through transit compartments 1 [Tr1] and 2 [Tr2]). See Table 1 for parameter estimates.