FIG 5.
Prediction from the final model of LPS/endotoxin release under various cefuroxime treatment regimens during infection of pathogens with three MIC values (2, 8, and 32 mg/liter) (shown in the key) at an inoculum of 106 CFU/ml. Treatment regimens shown are constant infusion (CI) preceded by a 4-min infusion of 750 mg and 30-min infusions of 750 mg given every 6 h (q6h) and 750 and 1,500 mg given every 8 h (q8h). The horizontal dashed line in panel b indicates the lower limit of detection (10 CFU/ml).